Epigenetic Clocks and Brain Age: What a Biological-Age Test Cannot Promise
Understand epigenetic clocks, tissue-specific brain-age estimates, measurement uncertainty and why a younger score does not prove brain rejuvenation.
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Brain & Health Discoveries
Significant advances in neuroscience and health, explained with evidence, context and unanswered questions.
Lecanemab’s Traditional FDA Approval: Why Confirming Clinical Benefit Mattered
On July 6, 2023, the FDA converted Leqembi, the brand name for lecanemab-irmb, from accelerated to traditional approval for Alzheimer’s disease after a co
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Donanemab’s FDA Approval: Read the Trial Endpoint Before Comparing Headlines
On July 2, 2024, the FDA announced approval of Kisunla, or donanemab-azbt, for Alzheimer’s disease. The decision was important, but the evidence is best u
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GLP-1 Drugs and Dementia Risk: What Observational Studies Cannot Prove
Several large observational studies link GLP-1 drugs to lower dementia risk in people with type 2 diabetes, but observational data
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